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Conclusion: Our study demonstrates the dysregulation of the tRNA-aminoacylation machinery in aggressive HCC and the potential of these proteins, specially VARS1, as therapeutic targets in HCC

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The chimeric conjugates demonstrated consistent therapeutic potential across experimental models: it first effectively reduced PD-L1 levels in tumour cell lines, including those with high baseline PD-L1 expression and others resistant to immune checkpoint inhibitors

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Wei H, Desouki MM, Lin S, Xiao D, Franklin RB, Feng P